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human resolvin d1 elisa kit  (Cayman Chemical)


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    Cayman Chemical human resolvin d1 elisa kit
    Distribution of the levels of the markers in plasma and CSF among patients (n = 65) and controls (n = 43). ( A ) The differences in resolvins between patients with chronic epilepsy and controls. The levels of <t>RvD1</t> and RvE1 both in plasma and CSF were lower in epilepsy patients than controls. ( B ) The differences in pro-inflammatory markers between patients with chronic epilepsy and controls. The plasma levels of IL-1β and TNF-α were significantly increased in patients compared to controls, while the CSF levels of IL-1β and IL-6 were significantly higher than controls. No difference was found in the levels of plasma IL-6 and CSF TNF-α between the two groups. *** P < 0.001, ** P < 0.01, * P < 0.05, ns, no statistical difference. Unpaired t -test. Data are shown as mean ± SEM.
    Human Resolvin D1 Elisa Kit, supplied by Cayman Chemical, used in various techniques. Bioz Stars score: 90/100, based on 1 PubMed citations. ZERO BIAS - scores, article reviews, protocol conditions and more
    https://www.bioz.com/product/resolvins+d1/resolvin+d1+elisa+assay/pmc12212349-65-16-27
    Average 90 stars, based on 1 article reviews
    human resolvin d1 elisa kit - by Bioz Stars, 2026-09
    90/100 stars

    Images

    1) Product Images from "Decrease of Resolvin D1 and E1 in Patients with Chronic Epilepsy, Implicating Dysfunction of Neuroinflammation Resolution"

    Article Title: Decrease of Resolvin D1 and E1 in Patients with Chronic Epilepsy, Implicating Dysfunction of Neuroinflammation Resolution

    Journal: Journal of Inflammation Research

    doi: 10.2147/JIR.S521679

    Distribution of the levels of the markers in plasma and CSF among patients (n = 65) and controls (n = 43). ( A ) The differences in resolvins between patients with chronic epilepsy and controls. The levels of RvD1 and RvE1 both in plasma and CSF were lower in epilepsy patients than controls. ( B ) The differences in pro-inflammatory markers between patients with chronic epilepsy and controls. The plasma levels of IL-1β and TNF-α were significantly increased in patients compared to controls, while the CSF levels of IL-1β and IL-6 were significantly higher than controls. No difference was found in the levels of plasma IL-6 and CSF TNF-α between the two groups. *** P < 0.001, ** P < 0.01, * P < 0.05, ns, no statistical difference. Unpaired t -test. Data are shown as mean ± SEM.
    Figure Legend Snippet: Distribution of the levels of the markers in plasma and CSF among patients (n = 65) and controls (n = 43). ( A ) The differences in resolvins between patients with chronic epilepsy and controls. The levels of RvD1 and RvE1 both in plasma and CSF were lower in epilepsy patients than controls. ( B ) The differences in pro-inflammatory markers between patients with chronic epilepsy and controls. The plasma levels of IL-1β and TNF-α were significantly increased in patients compared to controls, while the CSF levels of IL-1β and IL-6 were significantly higher than controls. No difference was found in the levels of plasma IL-6 and CSF TNF-α between the two groups. *** P < 0.001, ** P < 0.01, * P < 0.05, ns, no statistical difference. Unpaired t -test. Data are shown as mean ± SEM.

    Techniques Used: Clinical Proteomics

    Correlations between resolvins and disease severity, as well as cognitive impairment in patients with chronic epilepsy. The plasma level of RvD1 (R = −0.291, P = 0.019) ( A ), plasma RvE1 (R = −0.301, P = 0.015) ( C ), and CSF RvE1 (R = −0.325, P = 0.008) ( D ) positively correlated with NHS3 scores, while CSF RvD1 (R = −0.129, P = 0.307) ( B ) of patients was not correlated with NHS3 scores. Plasma RvD1 level (R = 0.284, P = 0.022) ( E ) was positively correlated with MMSE scores of epilepsy patients, while CSF RvD1 (R = 0.243, P = 0.051) ( F ), plasma RvE1 (R = 0.071, P = 0.573) ( G ), and CSF RvE1 (R = 0.208, P = 0.097) ( H ) and of patients were not correlated with MMSE scores. Spearman correlation.
    Figure Legend Snippet: Correlations between resolvins and disease severity, as well as cognitive impairment in patients with chronic epilepsy. The plasma level of RvD1 (R = −0.291, P = 0.019) ( A ), plasma RvE1 (R = −0.301, P = 0.015) ( C ), and CSF RvE1 (R = −0.325, P = 0.008) ( D ) positively correlated with NHS3 scores, while CSF RvD1 (R = −0.129, P = 0.307) ( B ) of patients was not correlated with NHS3 scores. Plasma RvD1 level (R = 0.284, P = 0.022) ( E ) was positively correlated with MMSE scores of epilepsy patients, while CSF RvD1 (R = 0.243, P = 0.051) ( F ), plasma RvE1 (R = 0.071, P = 0.573) ( G ), and CSF RvE1 (R = 0.208, P = 0.097) ( H ) and of patients were not correlated with MMSE scores. Spearman correlation.

    Techniques Used: Clinical Proteomics

    Related Articles

    Expressing:

    Article Title: Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype
    Article Snippet: Primary human monocyte-derived MΦ were cocultured with MCF-7 breast carcinoma cells for 48 h or 100 nM resolvin D1 (Cayman Chemical, Michigan, USA) for 6 h. After 48 h, residual MCF-7 cells were removed from plates and cocultured, as well as resolvin D1-treated MΦ were collected for RNA isolation using the mirVana TM miRNA isolation kit (ThermoFisher Scientific, MA, USA) according to the manufacturer’s instructions.

    Article Title: Protective role of resolvin D1, a pro-resolving lipid mediator, in nonsteroidal anti-inflammatory drug-induced small intestinal damage
    Article Snippet: For the experiments to evaluate the effect of exogenous resolvin D1 on NSAID-induced small intestinal damage, 10 μg/kg BW of resolvin D1 (Cayman Chemical Company, Ann Arbor, MI, USA) in phosphate-buffered saline (PBS) was intraperitoneally administered 3 and 24 h before administration of indomethacin.

    Reverse Transcription Polymerase Chain Reaction:

    Article Title: Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype
    Article Snippet: Primary human monocyte-derived MΦ were cocultured with MCF-7 breast carcinoma cells for 48 h or 100 nM resolvin D1 (Cayman Chemical, Michigan, USA) for 6 h. After 48 h, residual MCF-7 cells were removed from plates and cocultured, as well as resolvin D1-treated MΦ were collected for RNA isolation using the mirVana TM miRNA isolation kit (ThermoFisher Scientific, MA, USA) according to the manufacturer’s instructions.

    Article Title: Protective role of resolvin D1, a pro-resolving lipid mediator, in nonsteroidal anti-inflammatory drug-induced small intestinal damage
    Article Snippet: For the experiments to evaluate the effect of exogenous resolvin D1 on NSAID-induced small intestinal damage, 10 μg/kg BW of resolvin D1 (Cayman Chemical Company, Ann Arbor, MI, USA) in phosphate-buffered saline (PBS) was intraperitoneally administered 3 and 24 h before administration of indomethacin.

    Immunohistochemical staining:

    Article Title: Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype
    Article Snippet: Primary human monocyte-derived MΦ were cocultured with MCF-7 breast carcinoma cells for 48 h or 100 nM resolvin D1 (Cayman Chemical, Michigan, USA) for 6 h. After 48 h, residual MCF-7 cells were removed from plates and cocultured, as well as resolvin D1-treated MΦ were collected for RNA isolation using the mirVana TM miRNA isolation kit (ThermoFisher Scientific, MA, USA) according to the manufacturer’s instructions.

    Article Title: Protective role of resolvin D1, a pro-resolving lipid mediator, in nonsteroidal anti-inflammatory drug-induced small intestinal damage
    Article Snippet: For the experiments to evaluate the effect of exogenous resolvin D1 on NSAID-induced small intestinal damage, 10 μg/kg BW of resolvin D1 (Cayman Chemical Company, Ann Arbor, MI, USA) in phosphate-buffered saline (PBS) was intraperitoneally administered 3 and 24 h before administration of indomethacin.

    Staining:

    Article Title: Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype
    Article Snippet: Primary human monocyte-derived MΦ were cocultured with MCF-7 breast carcinoma cells for 48 h or 100 nM resolvin D1 (Cayman Chemical, Michigan, USA) for 6 h. After 48 h, residual MCF-7 cells were removed from plates and cocultured, as well as resolvin D1-treated MΦ were collected for RNA isolation using the mirVana TM miRNA isolation kit (ThermoFisher Scientific, MA, USA) according to the manufacturer’s instructions.

    Article Title: Protective role of resolvin D1, a pro-resolving lipid mediator, in nonsteroidal anti-inflammatory drug-induced small intestinal damage
    Article Snippet: For the experiments to evaluate the effect of exogenous resolvin D1 on NSAID-induced small intestinal damage, 10 μg/kg BW of resolvin D1 (Cayman Chemical Company, Ann Arbor, MI, USA) in phosphate-buffered saline (PBS) was intraperitoneally administered 3 and 24 h before administration of indomethacin.

    Western Blot:

    Article Title: Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype
    Article Snippet: Primary human monocyte-derived MΦ were cocultured with MCF-7 breast carcinoma cells for 48 h or 100 nM resolvin D1 (Cayman Chemical, Michigan, USA) for 6 h. After 48 h, residual MCF-7 cells were removed from plates and cocultured, as well as resolvin D1-treated MΦ were collected for RNA isolation using the mirVana TM miRNA isolation kit (ThermoFisher Scientific, MA, USA) according to the manufacturer’s instructions.

    Article Title: Protective role of resolvin D1, a pro-resolving lipid mediator, in nonsteroidal anti-inflammatory drug-induced small intestinal damage
    Article Snippet: For the experiments to evaluate the effect of exogenous resolvin D1 on NSAID-induced small intestinal damage, 10 μg/kg BW of resolvin D1 (Cayman Chemical Company, Ann Arbor, MI, USA) in phosphate-buffered saline (PBS) was intraperitoneally administered 3 and 24 h before administration of indomethacin.

    Concentration Assay:

    Article Title: Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype
    Article Snippet: Primary human monocyte-derived MΦ were cocultured with MCF-7 breast carcinoma cells for 48 h or 100 nM resolvin D1 (Cayman Chemical, Michigan, USA) for 6 h. After 48 h, residual MCF-7 cells were removed from plates and cocultured, as well as resolvin D1-treated MΦ were collected for RNA isolation using the mirVana TM miRNA isolation kit (ThermoFisher Scientific, MA, USA) according to the manufacturer’s instructions.

    Article Title: Protective role of resolvin D1, a pro-resolving lipid mediator, in nonsteroidal anti-inflammatory drug-induced small intestinal damage
    Article Snippet: For the experiments to evaluate the effect of exogenous resolvin D1 on NSAID-induced small intestinal damage, 10 μg/kg BW of resolvin D1 (Cayman Chemical Company, Ann Arbor, MI, USA) in phosphate-buffered saline (PBS) was intraperitoneally administered 3 and 24 h before administration of indomethacin.

    Isolation:

    Article Title: Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype
    Article Snippet: Primary human monocyte-derived MΦ were cocultured with MCF-7 breast carcinoma cells for 48 h or 100 nM resolvin D1 (Cayman Chemical, Michigan, USA) for 6 h. After 48 h, residual MCF-7 cells were removed from plates and cocultured, as well as resolvin D1-treated MΦ were collected for RNA isolation using the mirVana TM miRNA isolation kit (ThermoFisher Scientific, MA, USA) according to the manufacturer’s instructions.

    Article Title: Protective role of resolvin D1, a pro-resolving lipid mediator, in nonsteroidal anti-inflammatory drug-induced small intestinal damage
    Article Snippet: For the experiments to evaluate the effect of exogenous resolvin D1 on NSAID-induced small intestinal damage, 10 μg/kg BW of resolvin D1 (Cayman Chemical Company, Ann Arbor, MI, USA) in phosphate-buffered saline (PBS) was intraperitoneally administered 3 and 24 h before administration of indomethacin.

    Derivative Assay:

    Article Title: Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype
    Article Snippet: Primary human monocyte-derived MΦ were cocultured with MCF-7 breast carcinoma cells for 48 h or 100 nM resolvin D1 (Cayman Chemical, Michigan, USA) for 6 h. After 48 h, residual MCF-7 cells were removed from plates and cocultured, as well as resolvin D1-treated MΦ were collected for RNA isolation using the mirVana TM miRNA isolation kit (ThermoFisher Scientific, MA, USA) according to the manufacturer’s instructions.

    Article Title: Protective role of resolvin D1, a pro-resolving lipid mediator, in nonsteroidal anti-inflammatory drug-induced small intestinal damage
    Article Snippet: For the experiments to evaluate the effect of exogenous resolvin D1 on NSAID-induced small intestinal damage, 10 μg/kg BW of resolvin D1 (Cayman Chemical Company, Ann Arbor, MI, USA) in phosphate-buffered saline (PBS) was intraperitoneally administered 3 and 24 h before administration of indomethacin.

    Positive Control:

    Article Title: Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype
    Article Snippet: Primary human monocyte-derived MΦ were cocultured with MCF-7 breast carcinoma cells for 48 h or 100 nM resolvin D1 (Cayman Chemical, Michigan, USA) for 6 h. After 48 h, residual MCF-7 cells were removed from plates and cocultured, as well as resolvin D1-treated MΦ were collected for RNA isolation using the mirVana TM miRNA isolation kit (ThermoFisher Scientific, MA, USA) according to the manufacturer’s instructions.

    Article Title: Protective role of resolvin D1, a pro-resolving lipid mediator, in nonsteroidal anti-inflammatory drug-induced small intestinal damage
    Article Snippet: For the experiments to evaluate the effect of exogenous resolvin D1 on NSAID-induced small intestinal damage, 10 μg/kg BW of resolvin D1 (Cayman Chemical Company, Ann Arbor, MI, USA) in phosphate-buffered saline (PBS) was intraperitoneally administered 3 and 24 h before administration of indomethacin.

    Transfection:

    Article Title: Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype
    Article Snippet: Primary human monocyte-derived MΦ were cocultured with MCF-7 breast carcinoma cells for 48 h or 100 nM resolvin D1 (Cayman Chemical, Michigan, USA) for 6 h. After 48 h, residual MCF-7 cells were removed from plates and cocultured, as well as resolvin D1-treated MΦ were collected for RNA isolation using the mirVana TM miRNA isolation kit (ThermoFisher Scientific, MA, USA) according to the manufacturer’s instructions.

    Article Title: Protective role of resolvin D1, a pro-resolving lipid mediator, in nonsteroidal anti-inflammatory drug-induced small intestinal damage
    Article Snippet: For the experiments to evaluate the effect of exogenous resolvin D1 on NSAID-induced small intestinal damage, 10 μg/kg BW of resolvin D1 (Cayman Chemical Company, Ann Arbor, MI, USA) in phosphate-buffered saline (PBS) was intraperitoneally administered 3 and 24 h before administration of indomethacin.

    Plasmid Preparation:

    Article Title: Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype
    Article Snippet: Primary human monocyte-derived MΦ were cocultured with MCF-7 breast carcinoma cells for 48 h or 100 nM resolvin D1 (Cayman Chemical, Michigan, USA) for 6 h. After 48 h, residual MCF-7 cells were removed from plates and cocultured, as well as resolvin D1-treated MΦ were collected for RNA isolation using the mirVana TM miRNA isolation kit (ThermoFisher Scientific, MA, USA) according to the manufacturer’s instructions.

    Article Title: Protective role of resolvin D1, a pro-resolving lipid mediator, in nonsteroidal anti-inflammatory drug-induced small intestinal damage
    Article Snippet: For the experiments to evaluate the effect of exogenous resolvin D1 on NSAID-induced small intestinal damage, 10 μg/kg BW of resolvin D1 (Cayman Chemical Company, Ann Arbor, MI, USA) in phosphate-buffered saline (PBS) was intraperitoneally administered 3 and 24 h before administration of indomethacin.

    Two Tailed Test:

    Article Title: Apoptotic tumor cell-derived microRNA-375 uses CD36 to alter the tumor-associated macrophage phenotype
    Article Snippet: Primary human monocyte-derived MΦ were cocultured with MCF-7 breast carcinoma cells for 48 h or 100 nM resolvin D1 (Cayman Chemical, Michigan, USA) for 6 h. After 48 h, residual MCF-7 cells were removed from plates and cocultured, as well as resolvin D1-treated MΦ were collected for RNA isolation using the mirVana TM miRNA isolation kit (ThermoFisher Scientific, MA, USA) according to the manufacturer’s instructions.

    Article Title: Protective role of resolvin D1, a pro-resolving lipid mediator, in nonsteroidal anti-inflammatory drug-induced small intestinal damage
    Article Snippet: For the experiments to evaluate the effect of exogenous resolvin D1 on NSAID-induced small intestinal damage, 10 μg/kg BW of resolvin D1 (Cayman Chemical Company, Ann Arbor, MI, USA) in phosphate-buffered saline (PBS) was intraperitoneally administered 3 and 24 h before administration of indomethacin.



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    Image Search Results


    5-LOX subcellular localization is a crucial factor influencing microglial function after SAH. A qPCR detection of inflammatory factors IL-1β, IL-6 and TNF-α after Zileuton intervention; B Flow cytometry detection of the mean fluorescence intensity of pHrodo after Zileuton intervention, and calculation of the phagocytic index; C WB detection of 5-LOX nuclear/cytoplasmic ratio in microglia after Zileuton intervention; D IF detection of the relative mean fluorescence intensity of 5-LOX in the nucleus after Zileuton intervention, bar = 20 μm; E Different subcellular localization of 5-LOX produces different metabolites; F qPCR detection of the inflammatory factors IL-1β, IL-6, and TNF-α after intervention with RvD1 or LXA4; G Flow cytometry was performed to detect the mean fluorescence intensity of pHrodo after RvD1 or LXA4 intervention, and the phagocytic index was calculated; H WB was performed to detect the nuclear/cytoplasmic protein ratio of 5-LOX after RvD1 intervention in microglia; I IF detection of the relative mean fluorescence intensity of 5-LOX in the nucleus after RvD1 intervention, bar = 20 μm; J ELISA detection of LTB4 content in microglia under different intervention conditions; K ELISA detection of LXA4 content in microglia under different intervention conditions; L LTB4/LXA4 ratio in microglia under different intervention conditions. * p <0.05, ** p <0.01, *** p <0.001, **** p <0.0001

    Journal: Journal of Neuroinflammation

    Article Title: P2X7-CaMKII drives 5-LOX nuclear translocation to impair microglial function after subarachnoid hemorrhage

    doi: 10.1186/s12974-025-03530-3

    Figure Lengend Snippet: 5-LOX subcellular localization is a crucial factor influencing microglial function after SAH. A qPCR detection of inflammatory factors IL-1β, IL-6 and TNF-α after Zileuton intervention; B Flow cytometry detection of the mean fluorescence intensity of pHrodo after Zileuton intervention, and calculation of the phagocytic index; C WB detection of 5-LOX nuclear/cytoplasmic ratio in microglia after Zileuton intervention; D IF detection of the relative mean fluorescence intensity of 5-LOX in the nucleus after Zileuton intervention, bar = 20 μm; E Different subcellular localization of 5-LOX produces different metabolites; F qPCR detection of the inflammatory factors IL-1β, IL-6, and TNF-α after intervention with RvD1 or LXA4; G Flow cytometry was performed to detect the mean fluorescence intensity of pHrodo after RvD1 or LXA4 intervention, and the phagocytic index was calculated; H WB was performed to detect the nuclear/cytoplasmic protein ratio of 5-LOX after RvD1 intervention in microglia; I IF detection of the relative mean fluorescence intensity of 5-LOX in the nucleus after RvD1 intervention, bar = 20 μm; J ELISA detection of LTB4 content in microglia under different intervention conditions; K ELISA detection of LXA4 content in microglia under different intervention conditions; L LTB4/LXA4 ratio in microglia under different intervention conditions. * p <0.05, ** p <0.01, *** p <0.001, **** p <0.0001

    Article Snippet: Zileuton(MedChemExpress, HY-14164, 20μM) [ ], BAPTA MedChemExpress, HY-100,168, 10μM [ ], RvD1 Aladdin, R341442, 25nM [ ], LXA4 Aladdin, L345922, 100nM [ ], JNJ MedChemExpress, HY-101,418, 100nM [ ].

    Techniques: Flow Cytometry, Fluorescence, Enzyme-linked Immunosorbent Assay

    Distribution of the levels of the markers in plasma and CSF among patients (n = 65) and controls (n = 43). ( A ) The differences in resolvins between patients with chronic epilepsy and controls. The levels of RvD1 and RvE1 both in plasma and CSF were lower in epilepsy patients than controls. ( B ) The differences in pro-inflammatory markers between patients with chronic epilepsy and controls. The plasma levels of IL-1β and TNF-α were significantly increased in patients compared to controls, while the CSF levels of IL-1β and IL-6 were significantly higher than controls. No difference was found in the levels of plasma IL-6 and CSF TNF-α between the two groups. *** P < 0.001, ** P < 0.01, * P < 0.05, ns, no statistical difference. Unpaired t -test. Data are shown as mean ± SEM.

    Journal: Journal of Inflammation Research

    Article Title: Decrease of Resolvin D1 and E1 in Patients with Chronic Epilepsy, Implicating Dysfunction of Neuroinflammation Resolution

    doi: 10.2147/JIR.S521679

    Figure Lengend Snippet: Distribution of the levels of the markers in plasma and CSF among patients (n = 65) and controls (n = 43). ( A ) The differences in resolvins between patients with chronic epilepsy and controls. The levels of RvD1 and RvE1 both in plasma and CSF were lower in epilepsy patients than controls. ( B ) The differences in pro-inflammatory markers between patients with chronic epilepsy and controls. The plasma levels of IL-1β and TNF-α were significantly increased in patients compared to controls, while the CSF levels of IL-1β and IL-6 were significantly higher than controls. No difference was found in the levels of plasma IL-6 and CSF TNF-α between the two groups. *** P < 0.001, ** P < 0.01, * P < 0.05, ns, no statistical difference. Unpaired t -test. Data are shown as mean ± SEM.

    Article Snippet: The levels of RvD1 and RvE1 in plasma and CSF of all subjects were measured by human resolvin D1 ELISA kit and human resolvin E1 ELISA kit (Cayman Chemical, USA) according to manufacturer’s instructions, the levels of cytokines including interleukin-1β (IL-1β), IL-6 and tumor necrosis factor-α (TNF-α) in plasma and CSF of patients and controls were analyzed by using ELISA kit (Jianglai Biological, China), following the manufacturer’s instructions.

    Techniques: Clinical Proteomics

    Correlations between resolvins and disease severity, as well as cognitive impairment in patients with chronic epilepsy. The plasma level of RvD1 (R = −0.291, P = 0.019) ( A ), plasma RvE1 (R = −0.301, P = 0.015) ( C ), and CSF RvE1 (R = −0.325, P = 0.008) ( D ) positively correlated with NHS3 scores, while CSF RvD1 (R = −0.129, P = 0.307) ( B ) of patients was not correlated with NHS3 scores. Plasma RvD1 level (R = 0.284, P = 0.022) ( E ) was positively correlated with MMSE scores of epilepsy patients, while CSF RvD1 (R = 0.243, P = 0.051) ( F ), plasma RvE1 (R = 0.071, P = 0.573) ( G ), and CSF RvE1 (R = 0.208, P = 0.097) ( H ) and of patients were not correlated with MMSE scores. Spearman correlation.

    Journal: Journal of Inflammation Research

    Article Title: Decrease of Resolvin D1 and E1 in Patients with Chronic Epilepsy, Implicating Dysfunction of Neuroinflammation Resolution

    doi: 10.2147/JIR.S521679

    Figure Lengend Snippet: Correlations between resolvins and disease severity, as well as cognitive impairment in patients with chronic epilepsy. The plasma level of RvD1 (R = −0.291, P = 0.019) ( A ), plasma RvE1 (R = −0.301, P = 0.015) ( C ), and CSF RvE1 (R = −0.325, P = 0.008) ( D ) positively correlated with NHS3 scores, while CSF RvD1 (R = −0.129, P = 0.307) ( B ) of patients was not correlated with NHS3 scores. Plasma RvD1 level (R = 0.284, P = 0.022) ( E ) was positively correlated with MMSE scores of epilepsy patients, while CSF RvD1 (R = 0.243, P = 0.051) ( F ), plasma RvE1 (R = 0.071, P = 0.573) ( G ), and CSF RvE1 (R = 0.208, P = 0.097) ( H ) and of patients were not correlated with MMSE scores. Spearman correlation.

    Article Snippet: The levels of RvD1 and RvE1 in plasma and CSF of all subjects were measured by human resolvin D1 ELISA kit and human resolvin E1 ELISA kit (Cayman Chemical, USA) according to manufacturer’s instructions, the levels of cytokines including interleukin-1β (IL-1β), IL-6 and tumor necrosis factor-α (TNF-α) in plasma and CSF of patients and controls were analyzed by using ELISA kit (Jianglai Biological, China), following the manufacturer’s instructions.

    Techniques: Clinical Proteomics